PXD039955

PXD039955 is an original dataset announced via ProteomeXchange.

Title	CD99-mediated immunological synapse formation potentiates CAR-T cell function
Description	Cross-talks between actin and microtubules underly various cellular processes. Using immune synapse model and via cytoskeleton dynamics analyses, here, we demonstrate that CD99 is critical for the actin and microtubule cross-talks and the coordinated reorganization, mediating their physical linkage near the microtubule-organizing center, lamella, and cell cortex. Via the transmembrane and cytoplasmic domains, CD99 interacts with MyoIIA and IQGAP1, and facilitates interaction between these two partners and their interactions with microtubules at the three linkage sites.
HostingRepository	PRIDE
AnnounceDate	2025-07-23
AnnouncementXML	Submission_2025-07-23_02:22:32.282.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Eugene C Yi
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-08 06:30:08	ID requested
1	2025-07-17 21:24:01	announced
⏵ 2	2025-07-23 02:22:32	announced	2025-07-23: Updated project metadata.

Dataset with its publication pending

submitter keyword: Immunology,CD99

Eugene Yi
contact affiliation	Seoul National University
contact email	euyi@snu.ac.kr
lab head
Eugene C Yi
contact affiliation	Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine or College of Pharmacy, Seoul National University, Republic of Korea
contact email	euyi@snu.ac.kr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD039955

PRIDE project URI

• PRIDE
  1. PXD039955
     1. Label: PRIDE project
     2. Name: CD99-mediated immunological synapse formation potentiates CAR-T cell function