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PXD039915

PXD039915 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe direct effect of mycophenolate mofetil on podocytes in nephrotoxic serum nephritis
DescriptionThe goal of our study was to characterize glomerulus and particularly podocyte biology during MMF treatment in an immune-triggered proteinuric glomerulopathy. Therefore, nephrotoxic serum nephritis was induced in three-week old wild-type mice. On day 3, half of the mice were treated with MMF (100 mg/kgBW/d p.o.) (NTS+MMF) for one week, the other half of animals with vehicle (NTS+veh). A further group without induction and treatment served as controls (C). On day 10, we performed proteomic analysis of glomeruli.
HostingRepositoryPRIDE
AnnounceDate2023-08-30
AnnouncementXMLSubmission_2023-08-30_01:00:19.749.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterPreranaWagle
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive Plus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-02-07 13:41:11ID requested
12023-08-30 01:00:20announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: super-resolution imaging, intracellular Ca2+ imaging, actin cytoskeleton, multiphoton microscopy, renal epithelial cell,immune complex-mediated glomerulopathy, mycophenolic acid, glomerular filtration barrier
Contact List
AgnesHackl
contact affiliationPediatric Nephrology, Department of Pediatrics Faculty of Medicine and University Hospital Cologne, Kerpener Street 62, 50937, Cologne, Germany
contact emailagnes.hackl@uk-koeln.de
lab head
PreranaWagle
contact affiliationCECAD Research Center
contact emailproteomics-facility@uni-koeln.de
dataset submitter
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Dataset FTP location
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