PXD039840

PXD039840 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomic characterization of Foreign Body Response towards silicone breast implants identifies chronological disease-relevant biomarker dynamics
Description	The aim of this work was to enlighten the disease progression from implant insertion and immediate tissue damage response reflected in (a) the acute wound proteome, and (b) the adsorption of chronic inflammatory wound proteins at implant surfaces. An intra-individual relative quantitation TMT-liquid chromatography-tandem mass spectrometry approach was applied to profile wound proteome formed around SMI the first five days post-implantation.
HostingRepository	PRIDE
AnnounceDate	2023-02-24
AnnouncementXML	Submission_2023-02-24_01:55:25.438.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	KlausFaserl
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-03 09:52:09	ID requested
⏵ 1	2023-02-24 01:55:25	announced

Dataset with its publication pending

submitter keyword: SMI (silicone mammary implants)

FBR (foreign body response)

wound healing

wound infection

capsular fibrosis

implant encapsulation

early-stage fibrosis

surface adsorption

immunomics

biomarkers

KlausFaserl
contact affiliation	Innsbruck Medical University, Biocenter, Institute of Medical Biochemistry
contact email	klaus.faserl@i-med.ac.at
lab head
KlausFaserl
contact affiliation	Innsbruck Medical University, Biocenter
contact email	klaus.faserl@i-med.ac.at
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/02/PXD039840

PRIDE project URI

• PRIDE
  1. PXD039840
     1. Label: PRIDE project
     2. Name: Quantitative proteomic characterization of Foreign Body Response towards silicone breast implants identifies chronological disease-relevant biomarker dynamics