PXD038966 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomics analysis on SETD2 loss induced ccRCC formation |
Description | Patients with polycystic kidney disease (PKD) encounter a high risk of clear cell renal cell carcinoma (ccRCC), a malignant tumor with dysregulated lipid metabolism. SET domain–containing 2 (SETD2) has been identified as an important tumor suppressor gene in ccRCC. However, the role of SETD2 in tumorigenesis during the transition from PKD to ccRCC remains largely unexplored. Herein, we performed metabolomics, lipidomics, transcriptomics and proteomics with SETD2 loss induced PKD-ccRCC transition mouse model. To characterize biological responses triggered by SETD2 deletion during PKD-ccRCC transition at the protein level, we conducted global proteomics studies. |
HostingRepository | PRIDE |
AnnounceDate | 2023-10-31 |
AnnouncementXML | Submission_2023-10-31_05:47:14.709.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Raohanyu |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-12-20 06:55:30 | ID requested | |
⏵ 1 | 2023-10-31 05:47:15 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
ProteomeXchange project tag: Cancer (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project |
submitter keyword: Polycystic kidney disease (PKD), SET domain–containing 2 (SETD2), Clear cell renal cell carcinoma (ccRCC) |
Contact List
XiantingDing |
contact affiliation | Shanghai Jiao Tong University |
contact email | dingxianting@sjtu.edu.cn |
lab head | |
Raohanyu |
contact affiliation | Shanghai Jiao Tong University |
contact email | raohanyu@sjtu.edu.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD038966
- Label: PRIDE project
- Name: Proteomics analysis on SETD2 loss induced ccRCC formation