PXD038560

PXD038560 is an original dataset announced via ProteomeXchange.

Title	The phosphoproteome of choroid plexus epithelial cells following infection with Neisseria meningitidis
Description	The Gram-negative bacterium Neisseria meningitidis causes meningitis in humans and has been demonstrated to manipulate or alter host signalling pathways during infection of the central nervous system. In this study, the phosphoproteome of an in vitro model of the blood-cerebrospinal fluid barrier was investigated during infection with the Neisseria meningitidis serogroup B (NmB) strain MC58 in presence and absence of the bacterial capsule. We show that the capsule deficient mutant has a higher impact on the phosphoproteome of the infected cells and identify potentially regulated pathways and cellular processes during infection.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:59:51.395.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rune Hertz Larsen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-05 06:26:41	ID requested
⏵ 1	2023-11-14 08:59:51	announced

Dataset with its publication pending

submitter keyword: TMT, Human, Exploris 480,Neisseria meningitidis, LCMS

Christian Schwerk
contact affiliation	Klinik für Kinder- und Jugendmedizin, Medizinische Fakultät Mannheim, Germany
contact email	christian.schwerk@medma.uni-heidelberg.de
lab head
Rune Hertz Larsen
contact affiliation	Biogenity
contact email	rhl@biogenity.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD038560

PRIDE project URI

• PRIDE
  1. PXD038560
     1. Label: PRIDE project
     2. Name: The phosphoproteome of choroid plexus epithelial cells following infection with Neisseria meningitidis