PXD037901 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | GABA regulates IL-1β production in macrophages |
Description | Neurotransmitters have been well-documented to determine immune cell fates; however, whether and how γ-amino butyric acid (GABA) shapes the function of innate immune cells is still obscure. Here, we demonstrated that GABA orchestrates macrophage maturation and inflammation. GABA treatment during macrophage maturation inhibits interleukin (IL)-1β production from inflammatory macrophages. Mechanistically, GABA enhances succinate-FAD-lysine demethylase1 (LSD1) signaling to regulate the histone demethylation of Bcl2l11 and Dusp2, lowering the formation of NLRP3-ASC-Caspase-1 complex. Meanwhile, GABA-succinate axis lowers succinylation of mitochondrial proteins to promote mitochondrial oxidative phosphorylation (OXPHOS). We also found that GABA alleviates the LPS-induced sepsis as well as high-fat diet-induced obesity in mice. Our study proves that GABA is potential in lessening the pro-inflammatory macrophage responses associating with metabolic reprogramming and protein succinylation, thus providing a strategy for treating macrophage-related inflammatory diseases. |
HostingRepository | PRIDE |
AnnounceDate | 2023-01-06 |
AnnouncementXML | Submission_2023-01-06_08:32:30.780.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | JianFu |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | succinylated residue |
Instrument | autoflex |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-11-03 04:11:59 | ID requested | |
1 | 2022-11-29 09:06:50 | announced | |
⏵ 2 | 2023-01-06 08:32:31 | announced | 2023-01-06: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Macrophage, Succinate, Succinylation,FAD, GABA |
Contact List
JianFu |
contact affiliation | South China Agricultural University |
contact email | arrow_f1997@qq.com |
lab head | |
JianFu |
contact affiliation | South China Agricultural University |
contact email | arrow_f1997@qq.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD037901
- Label: PRIDE project
- Name: GABA regulates IL-1β production in macrophages