PXD037892 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The Fgf/Erf/NCoR1/2 repressive axis controls trophoblast cell fate |
Description | Here, we demonstrate that upon inhibition of the Fgf/Erk pathway in mouse trophoblast stem cells (TSCs), the Ets2 repressor factor (Erf) interacts with components of the Nuclear Receptor Corepressor Complex 1 and 2 (NCoR1 and NCoR2). Upon attenuation of Fgf signalling, unphosphorylated, nuclear Erf recruits the NCoR1/2 complex to key trophoblast genes, brings about their transcriptional silencing and facilitates differentiation and placental development. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_09:00:21.305.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Richard Imre |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | methylthiolated residue; phosphorylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF; Orbitrap Fusion Lumos; Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-11-03 04:03:37 | ID requested | |
1 | 2023-04-26 01:02:39 | announced | |
⏵ 2 | 2023-11-14 09:00:21 | announced | 2023-11-14: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: trophoblast stem cells,Erf, NCoR2, NCoR1 |
Contact List
Paulina A. Latos |
contact affiliation | Center for Anatomy and Cell Biology, Medical University of Vienna, Schwarzspanierstrasse 17, A-1090 Vienna, Austria Tel.: +4314016037718 |
contact email | paulina.latos@meduniwien.ac.at |
lab head | |
Richard Imre |
contact affiliation | IMBA Vienna |
contact email | richard.imre@imba.oeaw.ac.at |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/04/PXD037892 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD037892
- Label: PRIDE project
- Name: The Fgf/Erf/NCoR1/2 repressive axis controls trophoblast cell fate