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PXD037844

PXD037844 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHuman Beta Defensin-2-mediated protection of human skin barrier in vitro; a mechanistic evaluation
DescriptionI this project we performed global proteomic and secretomic analyses, following HBD2 stimulation, with or without V8-mediated damage, demonstrating minimal impact of the peptide alone on undamaged cells and showing that HBD2 did not induce expression of known antiproteases, but rather may function by modulating expression of extracellular matrix proteins.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:58:35.178.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJimi Wills
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive Plus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-10-31 09:04:54ID requested
12023-02-09 07:03:37announced
22023-11-14 08:58:35announced2023-11-14: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Defensins
Antimicrobial Host Defence Peptide
Atopic Dermatitis
Staphylococcus aureus
Contact List
Donald J. Davidson
contact affiliationUniversity of Edinburgh Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, Scotland, UK
contact emailDonald.Davidson@ed.ac.uk
lab head
Jimi Wills
contact affiliationFirefinch Software Ltd formerly Univeristy of Edinburgh
contact emailjimi@firefinch.io
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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