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PXD037524

PXD037524 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMyeloperoxidase is a Critical Mediator of Anthracycline-induced Cardiomyopathy
DescriptionThe anthracycline doxorubicin is a commonly used chemotherapeutic drug that induces cardiomyopathy in almost 10% of patients. The aim of this study was to examine the role of the leukocyte-derived enzyme Myeloperoxidase (MPO) in pathogenesis of anthracycline-induced Cardiomyopathy (AICM). We performed proteomics on whole heart tissue of MPO-deficient mice on C57BL/6J background and wildtype (WT) littermates seven days after intravenous injection of the anthracycline Doxorubicin (20 mg/kg bodyweight, dissolved in saline) or saline (NaCl).
HostingRepositoryPRIDE
AnnounceDate2023-08-30
AnnouncementXMLSubmission_2023-08-30_01:08:54.686.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterPreranaWagle
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListiodoacetamide derivatized residue
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-10-18 08:02:09ID requested
12023-08-30 01:08:55announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: cardiotoxicity, polymorphonuclear neutrophils, AICM, MPO,Doxorubicin
Contact List
MartinMollenhauer
contact affiliationDepartment of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany
contact emailmartin.mollenhauer@uk-koeln.de
lab head
PreranaWagle
contact affiliationCECAD Research Center
contact emailproteomics-facility@uni-koeln.de
dataset submitter
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Dataset FTP location
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