PXD037524 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Myeloperoxidase is a Critical Mediator of Anthracycline-induced Cardiomyopathy |
Description | The anthracycline doxorubicin is a commonly used chemotherapeutic drug that induces cardiomyopathy in almost 10% of patients. The aim of this study was to examine the role of the leukocyte-derived enzyme Myeloperoxidase (MPO) in pathogenesis of anthracycline-induced Cardiomyopathy (AICM). We performed proteomics on whole heart tissue of MPO-deficient mice on C57BL/6J background and wildtype (WT) littermates seven days after intravenous injection of the anthracycline Doxorubicin (20 mg/kg bodyweight, dissolved in saline) or saline (NaCl). |
HostingRepository | PRIDE |
AnnounceDate | 2023-08-30 |
AnnouncementXML | Submission_2023-08-30_01:08:54.686.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | PreranaWagle |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-10-18 08:02:09 | ID requested | |
⏵ 1 | 2023-08-30 01:08:55 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: cardiotoxicity, polymorphonuclear neutrophils, AICM, MPO,Doxorubicin |
Contact List
MartinMollenhauer |
contact affiliation | Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany |
contact email | martin.mollenhauer@uk-koeln.de |
lab head | |
PreranaWagle |
contact affiliation | CECAD Research Center |
contact email | proteomics-facility@uni-koeln.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/08/PXD037524 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD037524
- Label: PRIDE project
- Name: Myeloperoxidase is a Critical Mediator of Anthracycline-induced Cardiomyopathy