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PXD037391

PXD037391 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleOxidized thioredoxin-1 restrains the NLRP1 inflammasome
DescriptionTo find cellular protein binding partners of the NLRP1 inflammasome, FLAG-tagged full length NLRP1 (or a GFP-FLAG protein control) was ectopically expressed in HEK 293T cells and affinity purified from cell lysates (Note: the NLRP1-FLAG-containing lysate samples were affinity purified in the presence or absence of excess proline) before proteins were reduced, alkylated, and trypsinized before TMT labelling and pooling of the differentially tested lysates to give three conditions (1. NLRP1-FLAG; 2. GFP-FLAG; 3. NLRP1-FLAG+proline) in duplicate. These data represent the results following sample and data processing.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:59:04.303.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterDaniel Ball
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-10-13 15:11:57ID requested
12022-11-04 11:18:37announced
22023-11-14 08:59:04announced2023-11-14: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: innate immunity, programmed cell death,inflammasome, chemical biology, pattern recognition receptors
Contact List
Daniel A. Bachovchin
contact affiliationDepartment of Chemical Biology Memorial Sloan Kettering Cancer Center New York, NY
contact emailbachovcd@mskcc.org
lab head
Daniel Ball
contact affiliationMemorial Sloan Kettering Cancer Center
contact emailballd@mskcc.org
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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