PXD037098 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Multi-omics Analyses Reveal Sex Differences in Mouse Renal Proximal Tubules |
Description | Sex-dependent differences in kidney function have been recognized. However, the molecular mechanisms underlying these differences remain largely unexplored. Advances in genomics and proteomic technologies now allow for an extensive characterization of sex differences. In this study, the authors apply multi-omics approaches integrating RNA-seq, ATAC-seq, and proteomics to investigate gene expression, chromatin accessibility, and protein expression between male and female mouse proximal tubules. This study identifies a large number of sex-biased genes and proteins associated with various kidney functions, including metabolism and transport processes. The authors demonstrate that sex differences may also arise from differences in interaction between transcription factors and accessible chromatin regions. A comprehensive web resource is provided to the research community to advance understanding of sex differences. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:58:05.773.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | CHIN-RANG YANG |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-09-30 03:57:44 | ID requested | |
1 | 2023-05-05 09:51:04 | announced | |
⏵ 2 | 2023-11-14 08:58:06 | announced | 2023-11-14: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Kidney, Multi-omics,Sex Difference |
Contact List
Mark A. Knepper |
contact affiliation | Epithelial Systems Biology Laboratory Systems Biology Center Division of Intramural Research National Heart, Lung and Blood Institute Building 10, Room 6N307 Bethesda, Maryland 20895-1603 |
contact email | knepperm@nhlbi.nih.gov |
lab head | |
CHIN-RANG YANG |
contact affiliation | National Institutes of Health, USA |
contact email | chin-rang.yang@nih.gov |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD037098
- Label: PRIDE project
- Name: Multi-omics Analyses Reveal Sex Differences in Mouse Renal Proximal Tubules