PXD036940 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Extracellular matrix educates a tumor macrophage phenotype found in ovarian cancer metastasis |
Description | Recent studies have shown the tumor extracellular matrix (ECM) associates with immunosuppression, and that targeting the ECM can improve immune infiltration and immunotherapy response. A question that remains is whether the ECM is directly educating the immune phenotypes seen in cancer. We identified a tumor-associated macrophage (TAM) population correlated with poor prognosis, interruption of the cancer immunity cycle, and tumor ECM composition. To investigate whether ECM was capable of generating the TAM phenotype seen, we developed a decellularized tissue model that retains the native ECM architecture and composition. Macrophages cultured on decellularized ovarian metastasis shared transcriptional profiles with the TAMs found in human tissues. ECM educated macrophages have a tissue remodeling and immunoregulatory phenotype, inducing altered T cell function. We conclude that the tumor ECM is directly educating this macrophage population found in cancer tissues. Therefore, current and emerging cancer therapies that target the tumor ECM may be tailored to improve macrophage phenotype and their downstream regulation of immunity. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_09:01:07.927.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD036940 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Vinothini Rajeeve |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-09-22 00:12:51 | ID requested | |
1 | 2023-04-11 05:43:05 | announced | |
⏵ 2 | 2023-11-14 09:01:08 | announced | 2023-11-14: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: cancer, Tumor-associated macrophages, proteomics,Decellularized tissue model, immunity, extracellular matrix, LC-MS/MS |
Contact List
Professor Pedro R Cutillas |
contact affiliation | Professor of Cell Signalling & Proteomics Centre for Genomics and Computational Biology Barts Cancer Institute Queen Mary, University of London John Vane Science Centre, Charterhouse Square, London EC1M 6BQ Tel: +44 (0)20 7882 8266 | Fax: +44 (0)20 7882 3891 |
contact email | p.cutillas@qmul.ac.uk |
lab head | |
Vinothini Rajeeve |
contact affiliation | Centre for Haemato Oncology |
contact email | v.rajeeve@qmul.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD036940
- Label: PRIDE project
- Name: Extracellular matrix educates a tumor macrophage phenotype found in ovarian cancer metastasis