PXD036497

PXD036497 is an original dataset announced via ProteomeXchange.

Title	Multi-Omics Integration Highlights the Role of Ubiquitination in Endometriosis Fibrosis
Description	In this study, we comprehensively profiled the ubiquitination landscape of endometriosis for the first time. Through proteomics, transcriptomics, and ubiquitylomics analyses of endometrial tissues from two patient cohorts, we uncovered significant dysregulation of ubiquitin-related enzymes and ubiquitinated proteins. By comparing tissues in pathological and healthy states, we delineated ubiquitinated proteins associated with the etiology of endometriosis and revealed their regulatory roles in relevant biological processes. We observed a pivotal role of ubiquitination in the fibrotic process, particularly in processes related to the activity of myofibroblasts and collagen deposition in ectopic tissues. Besides, we uncovered the downregulation of the E3 ubiquitin ligase TRIM33 in endometriotic tissues, along with its negative regulatory effect on fibrosis-related proteins TGFBR1/p-SMAD2/α-SMA/FN1 in vitro. It is important to note that, while our study provides compelling evidence supporting the crucial role of ubiquitination in endometriosis and the negative regulatory effect of TRIM33 on fibrosis, the specific regulatory mechanisms require further in-depth functional studies. This study contributes to a deeper understanding of endometriosis pathogenesis and highlights the potential of targeting ubiquitination pathways for therapeutic intervention in this debilitating condition.
HostingRepository	iProX
AnnounceDate	2024-04-09
AnnouncementXML	Submission_2024-10-17_20:18:01.187.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mengjie Yang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-04 21:39:59	ID requested
⏵ 1	2024-10-17 20:18:01	announced

Dataset with its publication pending

submitter keyword: Endometriosis, Proteome

Qionghua Chen
contact affiliation	School of Medicine, Xiamen University
contact email	cqhua616@126.com
lab head
Mengjie Yang
contact affiliation	School of Medicine, Xiamen University
contact email	ymj12_dc@126.com
dataset submitter

iProX dataset URI