PXD035477 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Characterization of the interactome profiling of Mycoplasma DnaK in cancer cell reveals interference with key cellular pathways |
Description | Chaperone proteins are redundant in nature and, to achieve their function, they bind a large repertoire of client proteins. DnaK is a bacterial chaperone protein that recognizes misfolded and aggregated proteins and drives their folding and intracellular trafficking. Some Mycoplasmas are associated with cancers, and we demonstrated that infection with a strain of Mycoplasma fermentans isolated in our lab promoted lymphoma in a mouse model. Its DnaK is expressed intracellularly in infected cells, it interacts with key proteins to hamper essential pathways related to DNA repair and p53 functions and uninfected cells can take-up extracellular DnaK. |
HostingRepository | PRIDE |
AnnounceDate | 2022-10-12 |
AnnouncementXML | Submission_2022-10-12_09:48:35.917.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | NicholasSherman |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-07-21 03:39:55 | ID requested | |
⏵ 1 | 2022-10-12 09:48:36 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: proteomics, cellular pathways, Chaperone protein, DnaK protein,Mycoplasma fermentans |
Contact List
DavideZella |
contact affiliation | Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA |
contact email | DZella@ihv.umaryland.edu |
lab head | |
NicholasSherman |
contact affiliation | University of Virginia |
contact email | nes3f@virginia.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD035477 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD035477
- Label: PRIDE project
- Name: Characterization of the interactome profiling of Mycoplasma DnaK in cancer cell reveals interference with key cellular pathways