PXD035309 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Lysine Acetylome Profiling Reveals Diverse Functions of Acetylation in Deinococcus Radiodurans |
Description | D. radiodurans is distinguished by the most radioresistant organism identified to date. Lysine acetylation is a highly conserved post-translational modification that plays an essential role in the regulation of many cellular processes and may contribute to its extraordinary radioresistance. We integrate acetyl-lysine enrichment strategy, high-resolution mass spectrometry, and bioinformatics to profile the lysine acetylated proteins for the first time. It is striking that almost half of the total annotated proteins are identified as acetylated forms, which is the largest acetylome dataset reported in D. radiodurans to date. The acetylated proteins are involved in metabolic pathways, propanoate metabolism, carbon metabolism, fatty acid metabolism, and the tricarboxylic acid cycle. The results of this study reinforce the notion that acetylation plays critical regulatory roles in diverse aspects of the cellular process, especially in DNA damage repair and metabolism. It provides insight into the roles of lysine acetylation in the robust resistance to radiation. |
HostingRepository | PRIDE |
AnnounceDate | 2022-08-09 |
AnnouncementXML | Submission_2022-08-09_01:10:37.671.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yongqian Zhang |
SpeciesList | scientific name: Deinococcus radiodurans R1; NCBI TaxID: 243230; |
ModificationList | acetylated residue |
Instrument | Q Exactive HF; ultraflex |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-07-13 08:24:09 | ID requested | |
⏵ 1 | 2022-08-09 01:10:38 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Deinococcus radiodurans |
Lysine acetylation |
DNA Damage |
Posttranslational modification |
Contact List
Yongqian Zhang |
contact affiliation | Beijing Institute of Technology |
contact email | zyq@bit.edu.cn |
lab head | |
Yongqian Zhang |
contact affiliation | Beijing Insititute of Technology |
contact email | zyq@bit.edu.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD035309
- Label: PRIDE project
- Name: Lysine Acetylome Profiling Reveals Diverse Functions of Acetylation in Deinococcus Radiodurans