<<< Full experiment listing

PXD035309

PXD035309 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleLysine Acetylome Profiling Reveals Diverse Functions of Acetylation in Deinococcus Radiodurans
DescriptionD. radiodurans is distinguished by the most radioresistant organism identified to date. Lysine acetylation is a highly conserved post-translational modification that plays an essential role in the regulation of many cellular processes and may contribute to its extraordinary radioresistance. We integrate acetyl-lysine enrichment strategy, high-resolution mass spectrometry, and bioinformatics to profile the lysine acetylated proteins for the first time. It is striking that almost half of the total annotated proteins are identified as acetylated forms, which is the largest acetylome dataset reported in D. radiodurans to date. The acetylated proteins are involved in metabolic pathways, propanoate metabolism, carbon metabolism, fatty acid metabolism, and the tricarboxylic acid cycle. The results of this study reinforce the notion that acetylation plays critical regulatory roles in diverse aspects of the cellular process, especially in DNA damage repair and metabolism. It provides insight into the roles of lysine acetylation in the robust resistance to radiation.
HostingRepositoryPRIDE
AnnounceDate2022-08-09
AnnouncementXMLSubmission_2022-08-09_01:10:37.671.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYongqian Zhang
SpeciesList scientific name: Deinococcus radiodurans R1; NCBI TaxID: 243230;
ModificationListacetylated residue
InstrumentQ Exactive HF; ultraflex
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-07-13 08:24:09ID requested
12022-08-09 01:10:38announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Deinococcus radiodurans
Lysine acetylation
DNA Damage
Posttranslational modification
Contact List
Yongqian Zhang
contact affiliationBeijing Institute of Technology
contact emailzyq@bit.edu.cn
lab head
Yongqian Zhang
contact affiliationBeijing Insititute of Technology
contact emailzyq@bit.edu.cn
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD035309
PRIDE project URI
Repository Record List
[ + ]