PXD035082 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic analysis of the secretome of a esxaA mutant Mycobacterium tuberculosis strain |
Description | Extracellular Mycobacterium tuberculosis (Mtb) aggregates can evade phagocytosis and intracellular host-cell defenses by inducing macrophage killing. We showed that Mtb aggregates require a functional ESX-1 type VII secretion system to induce cell death upon contact with macrophages. We used quantitative proteomics to compare the secretome of a esxA mutant strain with the wild type reference to identify secreted bacteria factors involved in macrophage death induction. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:57:17.117.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Chiara Toniolo |
SpeciesList | scientific name: Bacteria; NCBI TaxID: NCBITaxon:2; scientific name: Mycobacterium tuberculosis; NCBI TaxID: 1773; |
ModificationList | phosphorylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-07-04 15:00:59 | ID requested | |
1 | 2023-03-16 02:59:12 | announced | |
⏵ 2 | 2023-11-14 08:57:17 | announced | 2023-11-14: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Mycobacterium tuberculosis, esxA, secretome |
Contact List
john McKinney |
contact affiliation | School of Life Sciences, Swiss Federal Institute of Technology in Lausanne (EPFL) |
contact email | john.mckinney@epfl.ch |
lab head | |
Chiara Toniolo |
contact affiliation | Ecole Polotechnique Federale de Lausanne (EPFL), SV, GHI, UPKIN |
contact email | chiara.toniolo87@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD035082
- Label: PRIDE project
- Name: Proteomic analysis of the secretome of a esxaA mutant Mycobacterium tuberculosis strain