PXD034908

PXD034908 is an original dataset announced via ProteomeXchange.

Title	The muscle proteome reflects changes in mitochondrial function, cellular stress and proteolysis after 14 days of unilateral lower limb immobilization in active young men
Description	Skeletal muscle unloading due to joint immobilization induces skeletal muscle atrophy. However, the skeletal muscle proteome response to limb immobilization has not been investigated using SWATH methods. This study quantitatively characterized the muscle proteome at baseline, and after 3 and 14 d of unilateral lower limb (knee-brace) immobilization in 18 healthy young men (25.4 ±5.5 y, 81.2 ±11.6 kg). All muscle biopsies were obtained from the vastus lateralis muscle. Unilateral lower limb immobilization was preceded by four-weeks of exercise training to standardise acute training history, and 7 days of dietary provision to standardise energy/macronutrient intake. Dietary intake was also standardised/provided throughout the 14 d immobilization period.
HostingRepository	PRIDE
AnnounceDate	2022-08-26
AnnouncementXML	Submission_2022-08-25_18:01:23.305.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	THIRI ZAW
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	TripleTOF 6600

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-26 07:39:14	ID requested
⏵ 1	2022-08-25 18:01:23	announced

Dataset with its publication pending

submitter keyword: SWATH, human, skeletal muscle, immobilisation, muscle atrophy

Vernon Coffey
contact affiliation	Exercise and Sports Science Faculty of Health Sciences and Medicine Bond University, Gold Coast, Queensland, 4229 Australia
contact email	vcoffey@bond.edu.au
lab head
THIRI ZAW
contact affiliation	AUSTRALIAN PROTEOME ANALYSIS FACILITY, MQ UNIVERSITY
contact email	thiri.zaw@mq.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD034908

PRIDE project URI

• PRIDE
  1. PXD034908
     1. Label: PRIDE project
     2. Name: The muscle proteome reflects changes in mitochondrial function, cellular stress and proteolysis after 14 days of unilateral lower limb immobilization in active young men