<<< Full experiment listing

PXD034187

PXD034187 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHBO1 Catalyzes Lysine Benzoylation in Mammalian Cells
DescriptionLysine benzoylation (Kbz) is a newly discovered protein post-translational modification (PTM). This PTM can be stimulated by benzoate and contributes to gene expression. However, its regulatory enzymes and substrate proteins remain largely unknown, hindering further functional studies. Here we identified and validated the lysine acetyltransferase (KAT) HBO1 as a “writer” of Kbz in mammalian cells. In addition, we report the first benzoylome in mammalian cells, identifying 1747 Kbz sites, among them at least 77 are the HBO1-targeted Kbz substrates. Bioinformatics analysis showed that HBO1-targeted Kbz sites were involved in multiple processes, including chromatin remodeling, transcription regulation, immune regulation, and tumor growth. Our results thus identify key regulatory elements of the Kbz pathway, and reveal new enzymatic activity and functions of HBO1 in cellular physiology.
HostingRepositoryPRIDE
AnnounceDate2022-10-14
AnnouncementXMLSubmission_2022-10-14_05:48:32.282.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHeHuang
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-05-29 14:07:12ID requested
12022-10-14 05:48:32announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Lysine benzoylation, Post-translational modification, HBO1, Transferase
Contact List
HeHuang
contact affiliationChinese Academy of Sciences Shanghai Institute of Materia Medica
contact emailhhuang@simm.ac.cn
lab head
HeHuang
contact affiliationShanghai Institute of Materia Medica
contact emailhhuang.nu@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD034187
PRIDE project URI
Repository Record List
[ + ]