PXD034014 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The small RNA Teg41 is a pleiotropic regulator of virulence in Staphylococcus aureus |
Description | Staphylococcus aureus is Gram-positive commensal bacteria that can also cause human disease ranging from mild, self-resolving skin infections to life-threatening conditions like endocarditis, osteomyelitis, and septicemia. Previously we demonstrated a role for the S. aureus sRNA, Teg41 in regulating production of the alpha Phenol Soluble Modulin toxins (αPSMs). In this study, we further characterize the regulatory role of Teg41. RNAseq analysis shows Teg41 influences the abundance of not just the αPSM transcript, but a variety of other transcripts as well compared to wild type S. aureus. Proteomic analysis confirms that eliminating Teg41 from the cell influences both the cytoplasmic and secreted protein profile of S. aureus. Finally, we observe that the Teg41Δ3′ strain is more severely attenuated in two murine infection models than a ∆αPSM strain, indicating that Teg41 regulation reaches beyond the αPSMs. Overall, we show that Teg41 is a unique pleiotropic sRNA in S. aureus that influences several key cellular processes. |
HostingRepository | PRIDE |
AnnounceDate | 2022-10-03 |
AnnouncementXML | Submission_2022-10-03_06:13:44.121.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ronan Carroll |
SpeciesList | scientific name: Staphylococcus aureus; NCBI TaxID: 1280; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-05-20 10:43:26 | ID requested | |
⏵ 1 | 2022-10-03 06:13:44 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Staphylococcus aureus Teg41 PSM spa |
Contact List
Ronan Carroll |
contact affiliation | Department of Biological Sciences, Ohio University |
contact email | carrolr3@ohio.edu |
lab head | |
Ronan Carroll |
contact affiliation | Ohio University |
contact email | carrolr3@ohio.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD034014
- Label: PRIDE project
- Name: The small RNA Teg41 is a pleiotropic regulator of virulence in Staphylococcus aureus