PXD033901 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Optogenetic rejuvenation of mitochondrial membrane potential extends C. elegans lifespan |
Description | Despite longstanding scientific interest in the centrality of mitochondria to biological aging, directly controlling mitochondrial function to test causality has eluded researchers. We show that specifically boosting mitochondrial membrane potential through a light-activated proton pump reversed age-associated phenotypes and extended C. elegans lifespan. We show that harnessing the energy of light to experimentally increase mitochondrial membrane potential during adulthood alone is sufficient to slow the rate of aging. |
HostingRepository | PRIDE |
AnnounceDate | 2022-11-11 |
AnnouncementXML | Submission_2022-11-10_23:58:57.396.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | ChristinaLudwig |
SpeciesList | scientific name: Caenorhabditis elegans; NCBI TaxID: 6239; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-05-16 06:46:44 | ID requested | |
⏵ 1 | 2022-11-10 23:58:57 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: C. elegans,aging |
Contact List
ChristinaLudwig |
contact affiliation | Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS), Technical University Munich (TUM), Freising, 85353, Germany |
contact email | tina.ludwig@tum.de |
lab head | |
ChristinaLudwig |
contact affiliation | TU Munich |
contact email | tina.ludwig@tum.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/11/PXD033901 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD033901
- Label: PRIDE project
- Name: Optogenetic rejuvenation of mitochondrial membrane potential extends C. elegans lifespan