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PXD033901

PXD033901 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleOptogenetic rejuvenation of mitochondrial membrane potential extends C. elegans lifespan
DescriptionDespite longstanding scientific interest in the centrality of mitochondria to biological aging, directly controlling mitochondrial function to test causality has eluded researchers. We show that specifically boosting mitochondrial membrane potential through a light-activated proton pump reversed age-associated phenotypes and extended C. elegans lifespan. We show that harnessing the energy of light to experimentally increase mitochondrial membrane potential during adulthood alone is sufficient to slow the rate of aging.
HostingRepositoryPRIDE
AnnounceDate2022-11-11
AnnouncementXMLSubmission_2022-11-10_23:58:57.396.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterChristinaLudwig
SpeciesList scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-05-16 06:46:44ID requested
12022-11-10 23:58:57announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: C. elegans,aging
Contact List
ChristinaLudwig
contact affiliationBavarian Center for Biomolecular Mass Spectrometry (BayBioMS), Technical University Munich (TUM), Freising, 85353, Germany
contact emailtina.ludwig@tum.de
lab head
ChristinaLudwig
contact affiliationTU Munich
contact emailtina.ludwig@tum.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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