PXD033687

PXD033687 is an original dataset announced via ProteomeXchange.

Title	METATAXONOMIC AND METAPROTEOMIC PROFILING OF THE ORAL MICROBIOME IN ORAL LICHEN PLANUS
Description	Background: A growing body of evidence demonstrates a different bacterial composition in the oral cavity of patients with oral lichen planus (OLP). Patients and methods: Buccal swab samples were collected from affected and non-affected sites of six patients with reticular OLP and the healthy oral mucosa of six control subjects. 16S rRNA MiSeq sequencing and mass spectrometry-based proteomics and were utilised to identify the metataxonomic and metaproteomic profiles of the oral microbiome in both groups. Results: The most abundant species in the three subgroups were Streptococcus oralis and Pseudomonas aeruginosa, accounting for up to 70% of the total population. A Canonical Correspondence Analysis showed differential clustering of samples from the healthy and OLP groups. Three species (Veillonella parvula, Actinomyces sp, and Lactococcus lactis) were significantly over-represented in the control group and one (Granulicatella elegans) in patients with OLP. The metaproteomic data revealed that several G. haemolysans-belonging peptidases and other proteins with inflammatory and virulence potential were found present in OLP lesions only. Conclusion: Our data suggest that several bacterial species and peptides are associated with OLP. Future studies with larger cohorts should be conducted to determine their role in the aetiology of OLP and evaluate their potential as disease biomarkers.
HostingRepository	PRIDE
AnnounceDate	2025-04-03
AnnouncementXML	Submission_2025-04-03_09:38:34.777.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Evelin Berger
SpeciesList	scientific name: Streptococcus oralis; NCBI TaxID: 1303;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-05 00:52:58	ID requested
⏵ 1	2025-04-03 09:38:35	announced

Dataset with its publication pending

submitter keyword: Oral cavity, oral mucosa, oral lichen planus, metataxonomics, oral microbiome, metaproteomics

Maria Bankvall
contact affiliation	OF Odontologi, OF Oral diagn & rehabilit Oral diagn & kirurgi, 171 77 Stockholm
contact email	maria.bankvall@ki.se
lab head
Evelin Berger
contact affiliation	Proteomics Core Facility, University of Gothenburg
contact email	evelin.berger@gu.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD033687

PRIDE project URI

• PRIDE
  1. PXD033687
     1. Label: PRIDE project
     2. Name: METATAXONOMIC AND METAPROTEOMIC PROFILING OF THE ORAL MICROBIOME IN ORAL LICHEN PLANUS