PXD033351 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Pan-cancer tumor-specific antigens and membrane targets from transposable elements |
Description | Cryptic promoters within transposable elements (TEs) are transcriptionally reactivated in tumors to create novel TE-gene chimeric transcripts, which can produce immunogenic antigens. We performed the most comprehensive screen to date for these TE exaptation events in 33 TCGA tumor types, 675 cancer cell lines, and 11,686 GTEx adult tissue transcriptomes and identified 1,068 TE-exapted candidates with the potential to generate shared tumor-specific TE-chimeric antigens (TS-TEAs). Resultant whole lysate and HLA-pulldown mass spectrometry data confirmed that TS-TEAs are presented on cancer cell surfaces. In addition, we highlight the tumor-specific membrane proteins transcribed from TE promoters that can expose novel epitopes on the extracellular surface of cancer cells. Here, we showcase the high pan-cancer prevalence of TS-TEAs and atypical membrane proteins that can be therapeutically exploited through immunotherapy approaches. |
HostingRepository | PRIDE |
AnnounceDate | 2023-01-21 |
AnnouncementXML | Submission_2023-01-20_21:10:02.623.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ju HeonMaeng |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-04-21 06:57:16 | ID requested | |
⏵ 1 | 2023-01-20 21:10:03 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Human, transposable element, antigen, Cancer, MHC pulldown, LC-MS/MS |
Contact List
TingWang |
contact affiliation | Department of Genetics, Washington University School of Medicine, St Louis, MO, USA The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA |
contact email | twang@genetics.wustl.edu |
lab head | |
Ju HeonMaeng |
contact affiliation | Washington University in St. Louis |
contact email | j.maeng@wustl.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/01/PXD033351 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD033351
- Label: PRIDE project
- Name: Pan-cancer tumor-specific antigens and membrane targets from transposable elements