PXD033053

PXD033053 is an original dataset announced via ProteomeXchange.

Title	Fish hydrolysate supplementation prevents stress-induced dysregulation of hippocampal proteins relative to mitochondrial metabolism and neuronal network in mice
Description	Over the past decades, stress incidence has dramatically increased in occidental societies. The use of natural resources, like fish hydrolysates, appeared as an interesting strategy to improve stress management. Our previous study demonstrated the anxiolytic effects of a fish hydrolysate supplementation in mice exposed to an acute mild stress, by limiting the stress-induced corticosterone release and modulating expression of some stress-responsive genes. Our work now explores hippocampal protein modulation induced by fish hydrolysate supplementation, in mice submitted to an acute mild stress, with the aim to better elucidate the underlying mechanisms. Hippocampi from the same cohort, Balb/c mice supplemented with fish hydrolysate (300 mg/kg body weight) or vehicle daily for 7 days before being submitted or not to an acute mild stress protocol (4 groups, n=8/group), were subjected to a label-free quantitative proteomics analysis conjugated with gene ontology data mining. Our results demonstrated that an acute mild stress modulated the expression of proteins involved in dopamine metabolism, neuron projection and metabolic process. Moreover, fish hydrolysate supplementation prevented stress-induced dysregulation of proteins relative to mitochondrial pathways and neuronal network. These findings suggest that fish hydrolysate represents an innovative strategy to prevent stress-induced aversive effects and participates in stress management.
HostingRepository	PRIDE
AnnounceDate	2022-05-30
AnnouncementXML	Submission_2022-05-30_06:43:32.202.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Julie Le Faouder
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2022-04-07 03:08:58	ID requested
⏵ 1	2022-05-30 06:43:32	announced

Dataset with its publication pending

submitter keyword: proteomics, hippocampus,fish hydrolysate, mitochondria, neuronal network, mouse, acute mild stress

Charles PIneau
contact affiliation	Univ Rennes, CNRS, Inserm, Biosit UAR 3480 US 018, Protim core facility, F-35000 Rennes, France
contact email	charles.pineau@univ-rennes1.fr
lab head
Julie Le Faouder
contact affiliation	Abyss Ingredients
contact email	julie@abyss-ingredients.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD033053
     1. Label: PRIDE project
     2. Name: Fish hydrolysate supplementation prevents stress-induced dysregulation of hippocampal proteins relative to mitochondrial metabolism and neuronal network in mice