PXD031853
PXD031853 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | CTNNBL1 restricts HIV-1 replication |
Description | Retroviral integration is mediated by a unique enzymatic process shared by all retroviruses and retrotransposons. During integration, double-stranded linear viral DNA is inserted into the host genome in a process catalyzed by viral-encoded integrase. However, host cell defenses against HIV-1 integration are not clear. This study identifies -catenin-like protein 1 (CTNNBL1) as a potent inhibitor of HIV-1 integration via association with viral IN and its cofactor, lens epithelium-derived growth factor/p75. CTNNBL1 overexpression blocks HIV-1 integration and inhibits viral replication, whereas CTNNBL1 depletion significantly upregulates HIV-1 integration into the genome of various target cells. Further, CTNNBL1 expression is downregulated in CD4+ T cells by activation, and CTNNBL1 depletion also facilitates HIV-1 integration in resting CD4+ T cells. Thus, host cells may employ CTNNBL1 to inhibit HIV-1 integration into the genome. This finding suggests a strategy for the treatment of HIV infections. |
HostingRepository | iProX |
AnnounceDate | 2022-02-24 |
AnnouncementXML | Submission_2022-02-23_17:55:46.088.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Guoxin Liang |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | phosphorylated residue; ubiquitination signature dipeptidyl lysine |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2022-02-23 17:55:33 | ID requested | |
⏵ 1 | 2022-02-23 17:55:46 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: CTNNBL1, HIV-1, LC-MC, IP, Ubiquitination, Phosphorylation |
Contact List
Guoxin Liang | |
---|---|
contact affiliation | China Medical University |
contact email | gxliang@cmu.edu.cn |
lab head | |
Guoxin Liang | |
contact affiliation | China Medical University |
contact email | gxliang@cmu.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |