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PXD031853

PXD031853 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCTNNBL1 restricts HIV-1 replication
DescriptionRetroviral integration is mediated by a unique enzymatic process shared by all retroviruses and retrotransposons. During integration, double-stranded linear viral DNA is inserted into the host genome in a process catalyzed by viral-encoded integrase. However, host cell defenses against HIV-1 integration are not clear. This study identifies -catenin-like protein 1 (CTNNBL1) as a potent inhibitor of HIV-1 integration via association with viral IN and its cofactor, lens epithelium-derived growth factor/p75. CTNNBL1 overexpression blocks HIV-1 integration and inhibits viral replication, whereas CTNNBL1 depletion significantly upregulates HIV-1 integration into the genome of various target cells. Further, CTNNBL1 expression is downregulated in CD4+ T cells by activation, and CTNNBL1 depletion also facilitates HIV-1 integration in resting CD4+ T cells. Thus, host cells may employ CTNNBL1 to inhibit HIV-1 integration into the genome. This finding suggests a strategy for the treatment of HIV infections.
HostingRepositoryiProX
AnnounceDate2022-02-24
AnnouncementXMLSubmission_2022-02-23_17:55:46.088.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterGuoxin Liang
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListphosphorylated residue; ubiquitination signature dipeptidyl lysine
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-02-23 17:55:33ID requested
12022-02-23 17:55:46announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: CTNNBL1, HIV-1, LC-MC, IP, Ubiquitination, Phosphorylation
Contact List
Guoxin Liang
contact affiliationChina Medical University
contact emailgxliang@cmu.edu.cn
lab head
Guoxin Liang
contact affiliationChina Medical University
contact emailgxliang@cmu.edu.cn
dataset submitter
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