PXD031356
PXD031356 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The Proteomic Characteristics of Rainbow Trout Blood with Severe, Moderate and Asymptomatic course of Vibrio anguillarum infection |
| Description | This data describes the clinical picture of natural Vibrio anguillarum infection in rainbow trout during an outbreak on a fish farm. Molecular mechanisms associated with the host immune response have been investigated using mass spectrometric analysis of trout plasma proteins. Three fish populations were identified among infected trout according to the severity of infection: fish with severe lesions (SL), with moderate infectious process (IP) and asymptomatic fish (AS). As expected, pro-inflammatory interleukins, complement components, acute phase proteins and antimicrobial peptides were implicated in the acute pathogenesis. Systemic coagulopathy was accompanied by increased antithrombotic reactions. Reconstruction of metabolic pathways also revealed a high energy requirement for the immune response in severely affected fish. An unexpected result was a small difference between fish with moderate symptoms and fish with no or minor external signs of pathology, proposed as resistant to infection. Increased production of antiproteases and enhanced blood coagulation cascade were observed in healthier fish, which may underlie the mechanisms of a controlled, non-self-damaging immune response to infection. |
| HostingRepository | MassIVE |
| AnnounceDate | 2022-01-31 |
| AnnouncementXML | Submission_2022-01-31_03:26:30.302.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Stanislav Kurpe |
| SpeciesList | scientific name: Oncorhynchus mykiss; common name: rainbow trout; NCBI TaxID: 8022; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-01-31 01:12:59 | ID requested | |
| ⏵ 1 | 2022-01-31 03:26:30 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Rainbow trout, plasma proteomics, LFQ , Vibrio anguillarum, Shotgun proteomic analysis, Vibriosis infections |
Contact List
| Irina V. Sukhovskaya | |
|---|---|
| contact affiliation | Institute of Biology of Karelian Research Centre of Russian Academy of Sciences |
| contact email | sukhovskaya@inbox.ru |
| lab head | |
| Ekaterina V. Borvinskaya | |
| contact affiliation | Institute of Biology of Irkutsk State University |
| contact email | borvinska@gmail.com |
| lab head | |
| Stanislav R. Kurpe | |
| contact affiliation | Institute of Protein Research of the Russian Academy of Sciences |
| contact email | st.kurpe@vega.protres.ru |
| lab head | |
| Stanislav Kurpe | |
| contact affiliation | Institute of Protein Research, Russian Academy of Sciences |
| contact email | st.kurpe@vega.protres.ru |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000088752/ |
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