PXD031199

PXD031199 is an original dataset announced via ProteomeXchange.

Title	A phylogenomic approach to explore the Aspergillus fumigatus conidia surforme and its role in pathogenesis
Description	Aspergillus fumigatus is the most important pulmonary fungal pathogen. Virulence has evolved several times in the section Aspergillii. However, there are species in this section, such as A. fischerii and A. oerlinghausensis, that are very closely related to A. fumigatus but are not reported as pathogens. By using trypsin shaving, we have identified the proteins on the conidial surface of conidia and swollen conidia of A. fumigatus, A. fischeri, A. oerlinghausensis, and A. lentulus. We have identified about 900 proteins in all four species and shown 52 that are unique in A. fumigatus. Both A. fischerii and A. oerlinghausensis have homologues for most of these proteins. However, they are not expressed in the conidia and and could reflect specific A. fumigatus traits important for infection and/or immune evasion.
HostingRepository	PRIDE
AnnounceDate	2024-06-26
AnnouncementXML	Submission_2024-06-26_04:59:40.469.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thomas Krüger
SpeciesList	scientific name: Neosartorya fumigata (Aspergillus fumigatus); NCBI TaxID: 746128; scientific name: Aspergillus oerlinghausenensis; NCBI TaxID: 1774284; scientific name: Neosartorya fischeri; NCBI TaxID: 36630; scientific name: Aspergillus lentulus; NCBI TaxID: 293939;
ModificationList	acetylated residue; monohydroxylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-01-24 03:18:03	ID requested
⏵ 1	2024-06-26 04:59:40	announced

Dataset with its publication pending

submitter keyword: conidia, asparaginase, macrophages,Aspergilli, surfome

Axel A. Brakhage
contact affiliation	Department of Molecular and Applied Microbiology Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute Jena, Germany
contact email	axel.brakhage@leibniz-hki.de
lab head
Thomas Krüger
contact affiliation	Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute
contact email	thomas.krueger@leibniz-hki.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD031199

PRIDE project URI

• PRIDE
  1. PXD031199
     1. Label: PRIDE project
     2. Name: A phylogenomic approach to explore the Aspergillus fumigatus conidia surforme and its role in pathogenesis