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PXD031144

PXD031144 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleRegulators of proteostasis are translationally repressed in fibroblasts from sporadic and LRRK2-G2019S Parkinson’s patients
DescriptionHere we used non-canonical amino acid labeling and mass-spectrometry based proteomics to perform a quantitative comparison of nascent proteins in fibroblasts from sporadic and G2019S mutation PD patients compared to healthy individuals. We found that several proteins were under-represented among nascent proteins in cells from PD patients. Among these were regulators endo-lysosomal sorting, mRNA processing and translation itself.
HostingRepositoryPRIDE
AnnounceDate2022-02-21
AnnouncementXMLSubmission_2022-02-21_03:38:01.671.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterDani Flinkman
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive; LTQ Orbitrap
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-01-21 07:39:03ID requested
12022-02-21 03:38:02announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Parkinson's disease, Protein synthesis
Contact List
Eleanor Coffey
contact affiliationTurku Bioscience, Abo Akademi and University of Turku
contact emailelecof@utu.fi
lab head
Dani Flinkman
contact affiliationTurku Bioscience
contact emaildkflin@utu.fi
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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