PXD031144 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Regulators of proteostasis are translationally repressed in fibroblasts from sporadic and LRRK2-G2019S Parkinson’s patients |
Description | Here we used non-canonical amino acid labeling and mass-spectrometry based proteomics to perform a quantitative comparison of nascent proteins in fibroblasts from sporadic and G2019S mutation PD patients compared to healthy individuals. We found that several proteins were under-represented among nascent proteins in cells from PD patients. Among these were regulators endo-lysosomal sorting, mRNA processing and translation itself. |
HostingRepository | PRIDE |
AnnounceDate | 2022-02-21 |
AnnouncementXML | Submission_2022-02-21_03:38:01.671.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Dani Flinkman |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive; LTQ Orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-01-21 07:39:03 | ID requested | |
⏵ 1 | 2022-02-21 03:38:02 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Parkinson's disease, Protein synthesis |
Contact List
Eleanor Coffey |
contact affiliation | Turku Bioscience, Abo Akademi and University of Turku |
contact email | elecof@utu.fi |
lab head | |
Dani Flinkman |
contact affiliation | Turku Bioscience |
contact email | dkflin@utu.fi |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD031144
- Label: PRIDE project
- Name: Regulators of proteostasis are translationally repressed in fibroblasts from sporadic and LRRK2-G2019S Parkinson’s patients