PXD030940 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Cell membrane remodeling mediates polymyxin B resistance in Klebsiella pneumoniae: an integrated proteomics and metabolomics study |
Description | In this study, resistance of Klebsiella pneumoniae (K. pneumoniae) to PB was induced by passaging in serial concentrations of PB. This study employed TMT-labeled quantitative proteomics and LC-MS/MS metabolomics analysis to investigate the key biological processes associated with PB resistance in K. pneumoniae. A total of 315 differentially expressed proteins (DEPs) were identified, of which 133 were upregulated, and 182 were downregulated in the PB resistant K. pneumoniae. Metabolomics data demonstrated that 23 metabolites were significantly upregulated in PB resistant K. pneumoniae, 5 were downregulated. |
HostingRepository | PRIDE |
AnnounceDate | 2022-01-24 |
AnnouncementXML | Submission_2022-01-24_08:33:16.555.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Xinyi Chen |
SpeciesList | scientific name: Klebsiella pneumoniae LCT-KP289; NCBI TaxID: 1352933; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-01-13 07:55:32 | ID requested | |
⏵ 1 | 2022-01-24 08:33:16 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: proteomics, metabolomics, Klebsiella pneumoniae, polymyxin B resistance, membrane remodeling |
Contact List
Min Wang |
contact affiliation | Department of Laboratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, China |
contact email | wangmin0000@csu.edu.cn |
lab head | |
Xinyi Chen |
contact affiliation | The Second Xiangya Hospital of Central South University |
contact email | cxy208211093@csu.edu.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD030940
- Label: PRIDE project
- Name: Cell membrane remodeling mediates polymyxin B resistance in Klebsiella pneumoniae: an integrated proteomics and metabolomics study