PXD030818 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Quantitative proteomic study reveals differential expression of matricellular proteins between fibrous dysplasia and cemento-ossifying fibroma pathogenesis |
Description | Fibrous dysplasia (FD) and cemento-ossifying fibroma (COF) are benign fibrous-osseous lesions of the maxillofacial bones that exhibit numerous similarities in their clinicopathological aspects. However, due to differences in their clinical evolution and treatment, it is essential to diagnose these diseases with accuracy. The differences in the pathogeneses of FD and COF are largely unknown and currently there is no biomarker available for their differential diagnosis. Nonetheless, there are few studies comparing these lesions and predominantly comprised of immunohistochemical investigations of traditional bone biomarkers. Therefore, the present study aimed to quantitatively compare the proteomic and phosphoproteomic profiles of cemento-ossifying fibroma and fibrous dysplasia to shed light onto the mechanisms involved in their molecular pathogenesis and identify potential differential diagnosis biomarkers. |
HostingRepository | PRIDE |
AnnounceDate | 2022-03-14 |
AnnouncementXML | Submission_2022-03-14_09:43:00.822.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Marcella N Melo-Braga |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-01-07 12:46:03 | ID requested | |
⏵ 1 | 2022-03-14 09:43:01 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
ProteomeXchange project tag: Human Proteome Project |
submitter keyword: Formalin-fixed paraffin-embedded (FFPE), proteomics |
phosphoproteomics, ossifying fibroma, fibrous dysplasia, bone tumors, fibro-osseous lesions |
Contact List
Ricardo Santiago Gomez |
contact affiliation | Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais |
contact email | rsgomez@ufmg.br |
lab head | |
Marcella N Melo-Braga |
contact affiliation | Universidade Federal de Minas Gerais |
contact email | marcellanmb@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/03/PXD030818 |
PRIDE project URI |
Repository Record List
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[ - ]
- PRIDE
- PXD030818
- Label: PRIDE project
- Name: Quantitative proteomic study reveals differential expression of matricellular proteins between fibrous dysplasia and cemento-ossifying fibroma pathogenesis