PXD030128

PXD030128 is an original dataset announced via ProteomeXchange.

Title	Label-Free Proteomics-based analysis of peripheral nerve injury induced by Japanese encephalitis virus
Description	Japanese encephalitis (JE) is an acute encephalitis syndrome contributed to Japanese encephalitis virus (JEV) infection. It is the chief cause of viral encephalitis in Asian. In recent years, association of JEV infection with neurological problems such as Guillain-Barré syndrome had reported. Nevertheless, its potential pathogenic mechanism has never been reported. Therefore, it is urgent to explore the relationship between peripheral nerve injury and JEV infection. Here, we use the liquid chromatography-tandem mass spectrometry (LC-MS/MS) technique to make out the protein expression levels of mice sciatic nerve between JEV infection group and the sham group. In general, 4303 proteins were identified by MS, and 187 differentially expressed proteins were found. There were 105 proteins up-regulated in the injured sciatic nerve, and 82 proteins were down-regulated. Functional enrichment analysis of differentially expressed proteins showed that the up-regulated proteins were mainly related to immune regulatory response, and the down-regulated proteins were related to ribosomal structural components and translation.
HostingRepository	PRIDE
AnnounceDate	2022-05-27
AnnouncementXML	Submission_2022-05-27_01:28:54.925.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wang Xiaoli
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-12-02 04:44:47	ID requested
⏵ 1	2022-05-27 01:28:55	announced

Dataset with its publication pending

submitter keyword: Proteomics, JEV, peripheral nerve injury, differentially expressed proteins

Zhenhai Wang
contact affiliation	Neurology Center, Ningxia Medical University General Hospital, Yinchuan, Ningxia, China
contact email	wangzhenhai1968@163.com
lab head
Wang Xiaoli
contact affiliation	Ningxia Medical University
contact email	13995061030@163.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD030128
     1. Label: PRIDE project
     2. Name: Label-Free Proteomics-based analysis of peripheral nerve injury induced by Japanese encephalitis virus