PXD029635 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomics investigations of potential protein biomarkers in sera of rabbits infected with Schistosoma japonicum |
Description | Schistosomiasis is a chronic parasitic disease that continues to be a pressing public health problem in many developing countries. The primary pathological damage from the disease is granuloma and fibrosis caused by egg aggregation, and early treatment can effectively prevent the occurrence of liver fibrosis. Therefore, it is very important to identify biomarkers that can be used for early diagnosis of Schistosoma japonicum infection. In this study, a label-free proteomics method was performed to observe the alteration of proteins before infection, 1 week, and 6 weeks after infection, as well as 5 weeks and 7 weeks after treatment. A total of 10 proteins derived from S. japonicum and 242 host-derived proteins were identified and quantified as significantly changed. Temporal analysis was carried out to further analyze potential biomarkers with coherent changes during infection and treatment. The results revealed biological process changes in serum proteins compared to infection and treatment groups, which implicated receptor-mediated endocytosis, inflammatory response, and acute-phase response such as Mannan binding lectin serine peptidase 1, immunoglobulin, and phosphoglycerate mutase. These findings offer guidance for in-depth analysis of potential biomarkers of Schistosomiasis, host protein, and early diagnosis of S. japonica and its pathogenesis. |
HostingRepository | PRIDE |
AnnounceDate | 2021-12-20 |
AnnouncementXML | Submission_2021-12-20_11:48:25.974.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Nian-Nian Bi |
SpeciesList | scientific name: Oryctolagus cuniculus; NCBI TaxID: 9986; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-11-09 06:07:57 | ID requested | |
⏵ 1 | 2021-12-20 11:48:26 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Schistosoma japonicum, proteomics, label free, biomarker, bioinformatics |
Contact List
Kun Yang |
contact affiliation | Key Laboratory of National Health and Family Planning Commission on Parasitic Disease Control and Pre-vention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, 117 Meiyuan Yangxiang, Wuxi 214064, Jiangsu, China. |
contact email | yangkun@jipd.com |
lab head | |
Nian-Nian Bi |
contact affiliation | Nanjing Medical University |
contact email | mylmbnn@163.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/12/PXD029635 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD029635
- Label: PRIDE project
- Name: Proteomics investigations of potential protein biomarkers in sera of rabbits infected with Schistosoma japonicum