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PXD029321

PXD029321 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAnti-SARS-CoV-2 antibodies elicited by COVID-19mRNA vaccine exhibits a unique glycosylation pattern
DescriptionMessenger RNA-based vaccines against COVID-19 induce a robust anti-SARS-CoV-2 antibody response with potent viral neutralization activity. Antibody effector functions is determined by its constant region subclasses as well as by its glycosylation patterns, but their role in vaccine efficacy is not well understood. Moreover, whether vaccination induce antibodies with similar Fc structures and protection potential as in COVID-19 patients remains unclear. Here, we analyzed BNT162b2 vaccine-induced IgG subclass distribution and Fc glycosylation patterns, as well as their potential to drive effector function via Fc-gamma receptors and complement pathways. We identified a unique Fc composition of these antiviral protein antibodies that is distinct from COVID-19 patients and convalescences. Vaccine-induced anti-spike SARS-CoV-2 IgG displayed a pro-inflammatory Fc profile and superior Fab- and Fc-mediated function, as compared to antibodies generated during natural viral infection. Moreover, differences in the kinetics of IgG Fc structure formation and their engagement with immune receptors were observed between different age groups. These data highlight the heterogeneity of the IgG Fc response to SARS-CoV-2 infection and vaccination and suggest that they differently support long-lasting protection.
HostingRepositoryPRIDE
AnnounceDate2021-11-29
AnnouncementXMLSubmission_2021-11-29_06:32:16.025.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterDavid Morgenstern
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-10-25 00:36:50ID requested
12021-11-29 06:32:16announced
Publication List
Dataset with its publication pending
Keyword List
ProteomeXchange project tag: Sars-cov-2, Covid-19
submitter keyword: SARS-CoV-2, Fc-glycosylation, antibody effector function, IgG, antibodies, COVID-19, mRNA vaccine, Fcγ receptors
Contact List
Rony Dahan
contact affiliationDepartment of Immunology, Weizmann institute of Science, Rehovot, Israel 7610001
contact emailrony.dahan@weizmann.ac.il
lab head
David Morgenstern
contact affiliationWeizmann institute
contact emaildavid.morgenstern@weizmann.ac.il
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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