PXD029291

PXD029291 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	N1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products
Description	The COVID mRNA vaccines utilize the modified nucleobase N1-methylpseudouridine, in place of canonical uridine, to improve immunogenicity and protein yield. However, relatively few studies have investigated the effect of modified nucleobases on the fidelity of protein translation. Given the interest in the COVID mRNA vaccines, we sought to investigate how N1-methylpseudouridine (and the related modification pseudouridine) is read by ribosomes.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:55:07.280.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD029291
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Kyusik Kim
SpeciesList	scientific name: Severe acute respiratory syndrome coronavirus 2; NCBI TaxID: 2697049;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos; Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-22 06:57:13	ID requested
1	2022-08-18 12:41:58	announced
⏵ 2	2023-11-14 08:55:08	announced	2023-11-14: Updated project metadata.

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

ProteomeXchange project tag: Sars-cov-2, Covid-19
submitter keyword: SARS-CoV-2, N1-methylpseudouridine, ribosome, decoding, fidelity, COVID-19, mRNA vaccine, translation

ProteomeXchange project tag: Sars-cov-2, Covid-19

submitter keyword: SARS-CoV-2, N1-methylpseudouridine, ribosome, decoding, fidelity, COVID-19, mRNA vaccine, translation

Contact List

Hani Zaher
contact affiliation	Department of Biology, Washington University in St. Louis
contact email	hzaher@wustl.edu
lab head
Kyusik Kim
contact affiliation	Washington University in St. Louis
contact email	kyusikkim@wustl.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD029291
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD029291

PRIDE project URI

Repository Record List

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