PXD029029

PXD029029 is an original dataset announced via ProteomeXchange.

Title	Citrullinated epitopes identified on tumor MHC class II by peptide elution stimulate both regulatory and Th1 responses and require careful selection for optimal tumor therapy
Description	In this manuscript, we outline the identification of citrullinated peptide epitopes presented on the surface of tumor cells that can be targeted for tumor therapy. Peptide elution from MHC is a useful tool in the identification of novel targets and has been used by many in immunotherapy strategies. Here we describe the identification of post-translationally modified citrullinated peptides through elution from MHC class II molecules.
HostingRepository	PRIDE
AnnounceDate	2021-11-24
AnnouncementXML	Submission_2021-11-24_01:43:45.271.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ana Marcu
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; L-citrulline
Instrument	LTQ Orbitrap XL

Revision	Datetime	Status	ChangeLog Entry
0	2021-10-10 22:52:11	ID requested
⏵ 1	2021-11-24 01:43:45	announced

Dataset with its publication pending

submitter keyword: Citrullinated epitopes, MHC class II, T cell responses

Lindy G Durrant
contact affiliation	Scancell Limited, Biodiscovery Institute, University Park, Science Road, Nottingham NG7 2RD. University of Nottingham, Biodiscovery Institute, Division of Cancer and Stem Cells, University Park, Science Road, Nottingham NG7 2RD.
contact email	Lindy.Durrant@nottingham.ac.uk
lab head
Ana Marcu
contact affiliation	University of Tübingen, Interfaculty Institute for Cell Biology, Department of Immunology
contact email	anamarcu.pe@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/11/PXD029029

PRIDE project URI

• PRIDE
  1. PXD029029
     1. Label: PRIDE project
     2. Name: Citrullinated epitopes identified on tumor MHC class II by peptide elution stimulate both regulatory and Th1 responses and require careful selection for optimal tumor therapy