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PXD028561

PXD028561 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleGlucose dissociates DDX21 dimers to regulate mRNA splicing and promote epidermal differentiation
DescriptionWe discovered that glucose directly bind to DDX21, induced the conformation change of the proteins and inhibit its helicase activity. Glucose also inhibits the dimerization of DDX21, re-localize DDX21 from nucleolus to nucleoplasm and reassemble DDX21 to RNA splicing complex. DDX21 is essential for epidermal differentiation while with normal glucose condition, DDX21 was re-localized from nucleolus to nucleoplasm, bind to splicing factors and mRNA introns more to regulate splicing of key differentiation factors and promote epidermal differentiation.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:53:26.174.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYen-Yu Yang
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive Plus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-09-16 07:40:21ID requested
12023-01-05 19:34:20announced
22023-11-14 08:53:26announced2023-11-14: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Proximity labeling,DDX21, splicing, glucose, BioID, epidermal differentiation
Contact List
Yinsheng Wang
contact affiliationDepartment of Chemistry, University of California Riverside
contact emailyinsheng@ucr.edu
lab head
Yen-Yu Yang
contact affiliationUC Riverside
contact emailyyang227@ucr.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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