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PXD028426

PXD028426 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteome-Wide Analysis of Lysine 2-Hydroxyisobutyrylation in the Aspergillus niger in Peanuts
DescriptionAspergillus niger is a very destructive pathogen causing severe peanut root rot, especially in the seeding stage of peanuts (Arachis hypogaea), and often leading to the death of the plant. Protein lysine 2-hydroxyisobutyrylation (Khib) is a newly detected post-translational modification identified in several species. In this study, we identified 5041 Khib sites on 1453 modified proteins in A. niger. Compared with five other species, A. niger has conserved and novel proteins. Bioinformatics analysis showed that Khib proteins are widely distributed in A. niger and are involved in many biological processes. GO and KEGG enrichment analyses revealed that Khib proteins were significantly enriched in many cellular compartments and pathways, such as ribosomes and proteasome subunits. A total of 223 Knib proteins were part of the PPI network, thus, suggesting that Knib proteins are associated with a large range of protein interactions and diverse pathways in the life processes of A. niger. Several identified proteins are involved in pathogenesis regulation. Our research provides the first comprehensive report of lysine 2-hydroxyisobutyrylation and an extensive database for potential functional studies on Knib proteins in this economically important fungus.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:52:39.396.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterXianliang Ma
SpeciesList scientific name: Aspergillus aff. niger A2; NCBI TaxID: 1096976;
ModificationListN-butanoylated residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-09-09 13:49:10ID requested
12022-07-31 04:54:59announced
22023-11-14 08:52:40announced2023-11-14: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: lysine 2-hydroxyisobutyrylation,Aspergillus niger, proteome
Contact List
Yucheng Chi
contact affiliationShandong Academy of Agricultural Sciences, Jinan, Shandong, China
contact email87626681@163.com
lab head
Xianliang Ma
contact affiliationMicrometer Biotech
contact emailmaxianliangyxz@163.com
dataset submitter
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Dataset FTP location
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