PXD027853
PXD027853 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Triazine pyridine Chemistry for Protein Labelling on Tyrosine. |
Description | Chemoselective reactions allowing for amino acid-specific modification are essential for protein bioconjugation and covalent drug development. Apart from Lysine and Cysteine with superior nucleophilic side chains, other amino acid-selective reactions are also needed but not well developed. Herein, we report the development of the biocompatible and catalyst-free triazine-pyridine chemistry (TPC) for tyrosine-specific labelling under physiological conditions and profiling in whole proteome. TPC exhibited high tyrosine chemoselectivity in biological systems, displayed potentials in tyrosine-guided protein labelling, and had biocompatibility in living cells. The development of TPC based tyrosine labelling agents would offer additional tools in native protein chemical modification. |
HostingRepository | MassIVE |
AnnounceDate | 2021-08-10 |
AnnouncementXML | Submission_2021-08-10_23:59:09.935.xml |
DigitalObjectIdentifier | |
ReviewLevel | Non peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Zhang Qing |
SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
ModificationList | unknown modification |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2021-08-10 23:47:53 | ID requested | |
⏵ 1 | 2021-08-10 23:59:10 | announced |
Publication List
no publication |
Keyword List
submitter keyword: Tyrosine labeling, Triazine-pyridine chemistry |
Contact List
Prof. Xuechen Li | |
---|---|
contact affiliation | The University of Hong Kong |
contact email | xuechenl@hku.hk |
lab head | |
Zhang Qing | |
contact affiliation | The University of Hong Kong |
contact email | zhangqing7864@163.com |
dataset submitter |
Full Dataset Link List
MassIVE dataset URI |
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