PXD027815

PXD027815 is an original dataset announced via ProteomeXchange.

Title	Proteomics analysis based upon TNBS-induced UC model rats
Description	Ulcerative colitis (UC), a chronic, nonspecific inflammatory bowel disease characterized by continuous and diffuse inflammatory changes in the colonic mucosa, requires novel treatment method. Photodynamic therapy (PDT), as a promising physico-chemical treatment method, were used to treat UC rats’ model with novel photosensitizer LD4 in this paper, the treatment effect and mechanism was investigated. LD4-PDT could improve the survival rate of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced UC model rats, decrease expression of interleukin (IL)-6, IL-1, tumor necrosis factor (TNF)-α, malondialdehyde (MDA), myeloperoxidase (MPO) and increase the expression of glutathione (GSH) and superoxide oxidase (SOD), while protecting the integrity of the intestinal epithelium. LD4-PDT treatment could rebuild the intestinal microflora composition and reprogram the colonic protein profiles in TNBS-induced rats to almost the normal state. Proteomics analysis based upon TNBS-induced UC model rats revealed that Amine oxidase copper-containing 1 (AOC1) was a potential target of LD4-PDT. Novel photosensitizer agent LD4-PDT represents an efficient treatment method for UC, and AOC1 may be a promising target.
HostingRepository	PRIDE
AnnounceDate	2021-09-24
AnnouncementXML	Submission_2021-09-24_14:25:41.940.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	yumei rong
SpeciesList	scientific name: Oryza sativa (Rice); NCBI TaxID: 4530;
ModificationList	monohydroxylated residue
Instrument	API 3000

Revision	Datetime	Status	ChangeLog Entry
0	2021-08-09 06:34:12	ID requested
⏵ 1	2021-09-24 14:25:42	announced

Dataset with its publication pending

submitter keyword: Ulcerative colitis，LC-MS/MS

tianjun liu
contact affiliation	Molecular Design and Nanotechnology, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College
contact email	liutianjun@hotmail.com
lab head
yumei rong
contact affiliation	Molecular Design and Nanotechnology, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College
contact email	1403281141@qq.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD027815
     1. Label: PRIDE project
     2. Name: Proteomics analysis based upon TNBS-induced UC model rats