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PXD027812

PXD027812 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteome landscape of schizophrenia in patient-derived cerebral organoids
DescriptionWe utilized patient-derived induced pluripotent stem cells (iPSCs) to generate 3D cerebral organoids to model neuropathology of Scz during this critical period. We discovered that Scz organoids exhibited ventricular neuropathology resulting in altered progenitor survival and disrupted neurogenesis. cz organoids principally differed not in their proteomic diversity, but specifically in their total quantity of disease and neurodevelopmental factors at the molecular level. Provides unique insights into the proteome landscape of schizophrenia in patient-derived cerebral organoids
HostingRepositoryPRIDE
AnnounceDate2021-11-17
AnnouncementXMLSubmission_2021-11-17_08:49:57.563.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterdavid greening
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-08-09 06:33:56ID requested
12021-11-17 08:49:57announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Proteome, schizophrenia, cerebral organoids, iPSC, neuropathology
Contact List
david greening
contact affiliationBaker Heart and Diabetes Institute
contact emaildavid.greening@baker.edu.au
lab head
david greening
contact affiliationBaker Heart and Diabetes Inst.
contact emaildavid.greening@baker.edu.au
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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