PXD027812 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteome landscape of schizophrenia in patient-derived cerebral organoids |
Description | We utilized patient-derived induced pluripotent stem cells (iPSCs) to generate 3D cerebral organoids to model neuropathology of Scz during this critical period. We discovered that Scz organoids exhibited ventricular neuropathology resulting in altered progenitor survival and disrupted neurogenesis. cz organoids principally differed not in their proteomic diversity, but specifically in their total quantity of disease and neurodevelopmental factors at the molecular level. Provides unique insights into the proteome landscape of schizophrenia in patient-derived cerebral organoids |
HostingRepository | PRIDE |
AnnounceDate | 2021-11-17 |
AnnouncementXML | Submission_2021-11-17_08:49:57.563.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | david greening |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-08-09 06:33:56 | ID requested | |
⏵ 1 | 2021-11-17 08:49:57 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Proteome, schizophrenia, cerebral organoids, iPSC, neuropathology |
Contact List
david greening |
contact affiliation | Baker Heart and Diabetes Institute |
contact email | david.greening@baker.edu.au |
lab head | |
david greening |
contact affiliation | Baker Heart and Diabetes Inst. |
contact email | david.greening@baker.edu.au |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD027812
- Label: PRIDE project
- Name: Proteome landscape of schizophrenia in patient-derived cerebral organoids