PXD027278

PXD027278 is an original dataset announced via ProteomeXchange.

Title	Candida albicans CUG codon translation, comparison with other yeasts
Description	Candida yeasts causing human infections are spread across the yeast phylum with Candida glabrata being related to Saccharomyces cerevisiae, Candida krusei grouping to Pichia spp., and Candida albicans, Candida parapsilosis and Candida tropicalis belonging to the CTG-clade. The latter lineage contains yeasts with an altered genetic code translating CUG codons as serine using a serine-tRNA with a mutated anticodon. It has been suggested that the CTG-clade CUG codons are mistranslated to a small extent as leucine due to mischarging of the serine-tRNA(CAG). The mistranslation was suggested to result in variable surface proteins explaining fast host adaptation and pathogenicity. Here, we re-assessed this potential mistranslation by high-resolution mass spectrometry-based proteogenomics of multiple CTG-clade yeasts, various C. albicans strains, isolated from colonized and from infected human body sites, and C. albicans grown in yeast and hyphal forms.
HostingRepository	PRIDE
AnnounceDate	2021-11-17
AnnouncementXML	Submission_2021-11-17_10:26:16.916.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Martin Kollmar
SpeciesList	scientific name: Candida albicans (Yeast); NCBI TaxID: 5476; scientific name: Candida dubliniensis CD36; NCBI TaxID: 573826; scientific name: Millerozyma acaciae; NCBI TaxID: 28986; scientific name: Candida albicans SC5314; NCBI TaxID: 237561; scientific name: Candida tropicalis; NCBI TaxID: 5482;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive; Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2021-07-13 21:58:47	ID requested
⏵ 1	2021-11-17 10:26:17	announced

Dataset with its publication pending

submitter keyword: Candida albicans, Candida dubliniensis, Candida tropicalis,

Martin Kollmar
contact affiliation	Group Systems Biology of Motor Proteins, Department of NMR-based Structural Biology, Max-Planck-Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany
contact email	mako@nmr.mpibpc.mpg.de
lab head
Martin Kollmar
contact affiliation	MPI for Biophysical Chemistry
contact email	mako@nmr.mpibpc.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/11/PXD027278

PRIDE project URI

• PRIDE
  1. PXD027278
     1. Label: PRIDE project
     2. Name: Candida albicans CUG codon translation, comparison with other yeasts