PXD027191 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Conserved exchange of paralog proteins during neuronal differentiation |
Description | Gene duplication enables the emergence of new functions by lowering the general evolutionary pressure. Previous studies have highlighted the role of specific paralog genes during cell differentiation, e.g., in chromatin remodeling complexes. It remains unexplored whether similar mechanisms extend to other biological functions and whether the regulation of paralog genes is conserved across species. Here, we analyze the expression of paralogs across human tissues, during development and neuronal differentiation in fish, rodents and humans. While ~80% of paralog genes are co-regulated, a subset of paralogs shows divergent expression profiles, contributing to variability of protein complexes. We identify 78 substitutions of paralog eggNOG pairs that occur during neuronal differentiation and are conserved across species. Among these, we highlight a substitution between the paralogs Sec23a and Sec23b subunits of the COPII complex. Altering the ratio between these two genes via silencing-RNA knockdown was able to influence neuronal differentiation in different ways. We propose that remodeling of the vesicular transport system via paralog substitutions is an evolutionary conserved mechanism enabling neuronal differentiation. |
HostingRepository | PRIDE |
AnnounceDate | 2022-03-07 |
AnnouncementXML | Submission_2022-03-07_10:16:39.431.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Emilio Cirri |
SpeciesList | scientific name: Danio rerio (Zebrafish) (Brachydanio rerio); NCBI TaxID: 7955; |
ModificationList | carbamoylated residue; acetylated residue; monohydroxylated residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-07-08 09:10:18 | ID requested | |
⏵ 1 | 2022-03-07 10:16:39 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: paralogs, neuronal differentiation, protein complexes |
Contact List
Alessandro Ori |
contact affiliation | Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) Beutenbergstraße 11 07745 Jena, Germany |
contact email | Alessandro.Ori@leibniz-fli.de |
lab head | |
Emilio Cirri |
contact affiliation | Leibniz Institute on Ageing Fritz Lipmann Institute Jena |
contact email | emilio.cirri@fli-leibniz.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
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[ - ]
- PRIDE
- PXD027191
- Label: PRIDE project
- Name: Conserved exchange of paralog proteins during neuronal differentiation