PXD026645 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Targeting DDR1 and DDR2 overcomes matrix-mediated melanoma cell adaptation to BRAF-targeted therapy |
Description | To investigate the contribution of fibroblast-derived extracellular matrices (ECMs) to the resistance to targeted therapies in BRAF-mutated melanoma cells, we generated native-like 3D ECMs from human primary fibroblasts obtained from healthy individuals or melanoma patients. Cell-derived matrices from human dermal fibroblasts (HDF), skin melanoma associated fibroblasts (MAF) and two different lymph node fibroblast reticular cells (FRC) were denuded of cells and their composition was analyzed by mass spectrometry. |
HostingRepository | PRIDE |
AnnounceDate | 2021-11-12 |
AnnouncementXML | Submission_2021-11-11_23:50:04.832.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | AUDEBERT Stephane |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue |
Instrument | Q Exactive Plus |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-06-11 06:23:41 | ID requested | |
⏵ 1 | 2021-11-11 23:50:05 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: melanoma, extracellular matrix, DDR, targeted therapies, resistance, LC-MSMS |
Contact List
Deckert Marcel |
contact affiliation | C3M – Inserm U1065 Centre Méditerranéen de Médecine Moléculaire Team: Microenvironment, signaling and cancer Bâtiment Universitaire ARCHIMED 151 route Saint Antoine de Ginestière BP 2 3194 06204 NICE CEDEX 3 |
contact email | Marcel.DECKERT@unice.fr |
lab head | |
AUDEBERT Stephane |
contact affiliation | Pharmacology department |
contact email | stephane.audebert@inserm.fr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/11/PXD026645 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD026645
- Label: PRIDE project
- Name: Targeting DDR1 and DDR2 overcomes matrix-mediated melanoma cell adaptation to BRAF-targeted therapy