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PXD026645

PXD026645 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTargeting DDR1 and DDR2 overcomes matrix-mediated melanoma cell adaptation to BRAF-targeted therapy
DescriptionTo investigate the contribution of fibroblast-derived extracellular matrices (ECMs) to the resistance to targeted therapies in BRAF-mutated melanoma cells, we generated native-like 3D ECMs from human primary fibroblasts obtained from healthy individuals or melanoma patients. Cell-derived matrices from human dermal fibroblasts (HDF), skin melanoma associated fibroblasts (MAF) and two different lymph node fibroblast reticular cells (FRC) were denuded of cells and their composition was analyzed by mass spectrometry.
HostingRepositoryPRIDE
AnnounceDate2021-11-12
AnnouncementXMLSubmission_2021-11-11_23:50:04.832.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAUDEBERT Stephane
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
InstrumentQ Exactive Plus
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-06-11 06:23:41ID requested
12021-11-11 23:50:05announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: melanoma, extracellular matrix, DDR, targeted therapies, resistance, LC-MSMS
Contact List
Deckert Marcel
contact affiliationC3M – Inserm U1065 Centre Méditerranéen de Médecine Moléculaire Team: Microenvironment, signaling and cancer Bâtiment Universitaire ARCHIMED 151 route Saint Antoine de Ginestière BP 2 3194 06204 NICE CEDEX 3
contact emailMarcel.DECKERT@unice.fr
lab head
AUDEBERT Stephane
contact affiliationPharmacology department
contact emailstephane.audebert@inserm.fr
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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