PXD026539 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | CDK4/6 inhibition promotes anti-tumor immunity |
Description | Pharmacologicalinhibitors of cyclin dependent kinases 4 and 6 (CDK4/6) are an approvedtreatment forhormone receptor-positive breast cancer and are currently under evaluation across hundreds of clinical trials for other cancertypes. The clinical success of these inhibitorsis largely attributedto well-defined tumor-intrinsic cytostatic mechanisms, while their emerging role as immunomodulatory agents is lessunderstood. Usingintegrated epigenomic, transcriptomic and proteomicanalyses, we demonstrateda novel action of CDK4/6inhibitorsin promoting the phenotypic and functional acquisition of immunological T cell memory.Short-term priming with a CDK4/6inhibitorpromoted long-termendogenousanti-tumor T cell immunityin mice, enhanced the persistence and therapeutic efficacy of chimeric antigen receptor (CAR)-T cells, and induced an RB-dependent T cell phenotype supportive offavorable responses to immune checkpoint blockade in melanoma patients.Together, thesemechanistic insights significantlybroaden the prospective utility of CDK4/6 inhibitors as clinical tools to boostanti-tumorT cell immunity. |
HostingRepository | PRIDE |
AnnounceDate | 2021-06-08 |
AnnouncementXML | Submission_2021-06-07_22:34:45.854.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jarrod Sandow |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue |
Instrument | timsTOF Pro |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-06-07 06:07:38 | ID requested | |
⏵ 1 | 2021-06-07 22:34:46 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: CDK4, t-cell, phosphoproteomics, CDK6 |
Contact List
Stephin J. Vervoort |
contact affiliation | Peter MacCallum Cancer Centre, 305 Grattan St Melbourne VIC 3000 |
contact email | stephin.vervoort@petermac.org |
lab head | |
Jarrod Sandow |
contact affiliation | WEHI |
contact email | sandow@wehi.edu.au |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/06/PXD026539 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD026539
- Label: PRIDE project
- Name: CDK4/6 inhibition promotes anti-tumor immunity