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PXD026539

PXD026539 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCDK4/6 inhibition promotes anti-tumor immunity
DescriptionPharmacologicalinhibitors of cyclin dependent kinases 4 and 6 (CDK4/6) are an approvedtreatment forhormone receptor-positive breast cancer and are currently under evaluation across hundreds of clinical trials for other cancertypes. The clinical success of these inhibitorsis largely attributedto well-defined tumor-intrinsic cytostatic mechanisms, while their emerging role as immunomodulatory agents is lessunderstood. Usingintegrated epigenomic, transcriptomic and proteomicanalyses, we demonstrateda novel action of CDK4/6inhibitorsin promoting the phenotypic and functional acquisition of immunological T cell memory.Short-term priming with a CDK4/6inhibitorpromoted long-termendogenousanti-tumor T cell immunityin mice, enhanced the persistence and therapeutic efficacy of chimeric antigen receptor (CAR)-T cells, and induced an RB-dependent T cell phenotype supportive offavorable responses to immune checkpoint blockade in melanoma patients.Together, thesemechanistic insights significantlybroaden the prospective utility of CDK4/6 inhibitors as clinical tools to boostanti-tumorT cell immunity.
HostingRepositoryPRIDE
AnnounceDate2021-06-08
AnnouncementXMLSubmission_2021-06-07_22:34:45.854.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJarrod Sandow
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-06-07 06:07:38ID requested
12021-06-07 22:34:46announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: CDK4, t-cell, phosphoproteomics, CDK6
Contact List
Stephin J. Vervoort
contact affiliationPeter MacCallum Cancer Centre, 305 Grattan St Melbourne VIC 3000
contact emailstephin.vervoort@petermac.org
lab head
Jarrod Sandow
contact affiliationWEHI
contact emailsandow@wehi.edu.au
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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