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PXD026288

PXD026288 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTumor temporal proteome profiling reveals the immunological triple offensive induced by synthetic anti-cancer Salmonella
DescriptionThe engineered “obligate” anaerobic Salmonella typhimurium strain YB1 shows a prominent ability to repress tumor growth and metastasis, which has great potential as a novel cancer immunotherapy. However, the antitumor mechanism of YB1 remains unelucidated. To resolve the proteome dynamics induced by the engineered bacteria, we applied tumor temporal proteome profiling on murine bladder tumors after intravenous injection of either YB1 or PBS as a negative control. Our data suggests that during the two weeks treatment of YB1 injections, the cured tumors experienced three distinct phases of the immune response. Two days after injection, the innate immune response was activated, particularly the complement and blood coagulation pathways. In the meantime, the phagocytosis was initiated. The professional phagocytes such as macrophages and neutrophils were recruited, especially the infiltration of M1 macrophages was enhanced. Seven days after injection, substantial amount of T cells was observed at the invasion margin of the tumor. As a result, the tumor shrunk significantly. Overall, the temporal proteome profiling can systematically reveal the YB1 induced immune responses in tumor, showing great promise for elucidating the mechanism of bacteria-mediated cancer immunotherapy.
HostingRepositoryPRIDE
AnnounceDate2021-08-13
AnnouncementXMLSubmission_2021-08-12_22:19:48.874.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterzhao wenjuan
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-05-26 07:35:34ID requested
12021-08-12 22:19:49announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Quantitative proteomics, cancer immunotherapy, engineered Salmonella, blood coagulation, M1 macrophage, tumor specific T cell
Contact List
Li Nan
contact affiliationDept. Chemical Proteomics, Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences
contact emailnan.li@siat.ac.cn
lab head
zhao wenjuan
contact affiliationInstitute of Synthetic Biology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences
contact emailwj.zhao1@siat.ac.cn
dataset submitter
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Dataset FTP location
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