PXD026288 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Tumor temporal proteome profiling reveals the immunological triple offensive induced by synthetic anti-cancer Salmonella |
Description | The engineered “obligate” anaerobic Salmonella typhimurium strain YB1 shows a prominent ability to repress tumor growth and metastasis, which has great potential as a novel cancer immunotherapy. However, the antitumor mechanism of YB1 remains unelucidated. To resolve the proteome dynamics induced by the engineered bacteria, we applied tumor temporal proteome profiling on murine bladder tumors after intravenous injection of either YB1 or PBS as a negative control. Our data suggests that during the two weeks treatment of YB1 injections, the cured tumors experienced three distinct phases of the immune response. Two days after injection, the innate immune response was activated, particularly the complement and blood coagulation pathways. In the meantime, the phagocytosis was initiated. The professional phagocytes such as macrophages and neutrophils were recruited, especially the infiltration of M1 macrophages was enhanced. Seven days after injection, substantial amount of T cells was observed at the invasion margin of the tumor. As a result, the tumor shrunk significantly. Overall, the temporal proteome profiling can systematically reveal the YB1 induced immune responses in tumor, showing great promise for elucidating the mechanism of bacteria-mediated cancer immunotherapy. |
HostingRepository | PRIDE |
AnnounceDate | 2021-08-13 |
AnnouncementXML | Submission_2021-08-12_22:19:48.874.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | zhao wenjuan |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-05-26 07:35:34 | ID requested | |
⏵ 1 | 2021-08-12 22:19:49 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Quantitative proteomics, cancer immunotherapy, engineered Salmonella, blood coagulation, M1 macrophage, tumor specific T cell |
Contact List
Li Nan |
contact affiliation | Dept. Chemical Proteomics, Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences |
contact email | nan.li@siat.ac.cn |
lab head | |
zhao wenjuan |
contact affiliation | Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences |
contact email | wj.zhao1@siat.ac.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD026288
- Label: PRIDE project
- Name: Tumor temporal proteome profiling reveals the immunological triple offensive induced by synthetic anti-cancer Salmonella