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PXD025742

PXD025742 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIn utero pulse-injection of isotopic amino acids quantifies protein turnover rates during murine fetal development
DescriptionProtein translational control is a highly regulated step in the gene expression program during development and tools to quantify protein synthesis rates in a developing fetus are lacking. Here, we developed a novel in utero approach to quantify tissue-specific translational kinetics of the nascent proteome during mouse fetal development. The translational kinetic profiles of developing organs displayed differentially expressed protein pathways and synthesis rates which correlated with known physiological changes during mouse development.
HostingRepositoryMassIVE
AnnounceDate2024-06-25
AnnouncementXMLSubmission_2024-06-25_09:12:34.477.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJosue Baeza
SpeciesList scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationListAcetyl; Oxidation; Carbamidomethyl
InstrumentQ Exactive; Q Exactive HF-X; Orbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-04-30 07:04:14ID requested
12024-06-25 09:12:34announced
Publication List
no publication
Keyword List
submitter keyword: protein turnover, pSILAC, pulse-SILAC, pulse chase, development, in utero
Contact List
Benjamin A. Garcia
contact affiliationDepartment of Biochemistry and Biophysics, University of Pennsylvania
contact emailbgarci@mail.med.upenn.edu
lab head
Josue Baeza
contact affiliationUniversity of Pennsylvania
contact emailbaezaj83@gmail.com
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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