PXD025676 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Suv4-20h2 protects from influenza virus infection through suppression of chromatin loop formation |
Description | The spatial organization of chromatin is known to be highly dynamic in response to environmental stress. However, it remains unknown how chromatin dynamics contributes to or modulate the disease pathogenesis. Here we show that upon influenza virus infection, H4K20me3 methyltransferase Suv4-20h2 binds the viral protein NP, which results in the inactivation of the Suv4-20h2 and the dissociation of cohesin from Suv4-20h2. Inactivation of Suv4-20h2 by virus infection or genetic deletion, leads to active loop formation at HoxC8-HoxC6 through the loading of cohesin to this region. HoxC8 and HoxC6 in turn enhance viral replication by inhibiting the Wnt--catenin mediated interferon response. Importantly, loss of Suv4-20h2 augments the influenza pathology in vivo. Thus, Suv4-20h2 acts as a safeguard against influenza virus infection though the suppression of a cohesin-mediated loop formation. |
HostingRepository | PRIDE |
AnnounceDate | 2021-05-13 |
AnnouncementXML | Submission_2021-05-13_03:21:11.293.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Masami Shiimori |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-04-27 22:39:42 | ID requested | |
⏵ 1 | 2021-05-13 03:21:11 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Mouse, MEF, Suv-420h2, Influenza virus |
Contact List
Yumiko Imai |
contact affiliation | Laboratory of the Regulation for Intractable Infectious Diseases, National Institute of Biomedical Innovation, Health and Nutrition, Japan |
contact email | y-imai@nibiohn.go.jp |
lab head | |
Masami Shiimori |
contact affiliation | National Institute of Biomedical Innovation, Health and Nutrition |
contact email | m-shiimori@nibiohn.go.jp |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD025676
- Label: PRIDE project
- Name: Suv4-20h2 protects from influenza virus infection through suppression of chromatin loop formation