PXD025138 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Prognostic accuracy of MALDI-TOF mass spectrometric analysis of plasma in COVID-19 |
Description | SARS-CoV-2 infection poses a global health crisis. In parallel with the ongoing world effort to identify therapeutic solutions, there is a critical need for improvement in the prognosis of COVID-19. Here, we report plasma proteome finger print that predict high (hospitalized)and low risk(outpatients) cases of COVID-19 identified by a platform that combines machine learning with matrix-assisted laser desorption ionization mass spectrometry (MALDI-TOF MS) analysis. Sample preparation, MS and data analysis parameters were optimized to achieve an overall accuracy of 92%, sensitivity of 93%, and specificity of 92% in dataset without feature selection. Further on, we identified two distinct regions in the MALDI-TOF profile belonging to the same proteoforms. Unbiased discrimination of high and low-risk COVID-19patients employing a technology that is currently in clinical use may have a prompt application in the noninvasive prognosis of COVID-19. Further validation will consolidate its clinical utility. |
HostingRepository | PRIDE |
AnnounceDate | 2021-06-22 |
AnnouncementXML | Submission_2021-06-21_22:38:55.477.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Giuseppe Palmisano |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | ultraflex |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-04-01 02:26:32 | ID requested | |
⏵ 1 | 2021-06-21 22:38:55 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
ProteomeXchange project tag: Covid-19 |
submitter keyword: COVID-19, SARS-CoV-2, Mass spectrometry, Biomarker, Plasma, Prognosis |
Contact List
Giuseppe Palmisano |
contact affiliation | GlycoProteomics Laboratory, Avenida Lineu Prestes 1374, sala 9, Butanta, Sao Paulo, SP, Brazil |
contact email | palmisano.gp@gmail.com |
lab head | |
Giuseppe Palmisano |
contact affiliation | University of Sao Paulo |
contact email | palmisano.gp@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD025138
- Label: PRIDE project
- Name: Prognostic accuracy of MALDI-TOF mass spectrometric analysis of plasma in COVID-19