PXD025125

PXD025125 is an original dataset announced via ProteomeXchange.

Title	Pathophysiological pathway differences in children who present with COVID-19 ARDS compared to COVID -19 induced MIS-C
Description	Background: COVID-19 has infected more than 100-million worldwide. Children appear less susceptible to COVID-19 and present with milder symptoms. Cases of children with COVID-19 developing clinical features of Kawasaki-disease have been described. Methods: We utilised SWATH-MS proteomics to determine the plasma proteins expressed in healthy children, children with multisystem inflammatory syndrome (MIS-C) and children with COVID-19 induced ARDS. Pathway analyses were performed to determine the affected pathways. Results: 76 proteins were differentially expressed across the groups, with 85 and 52 proteins specific to MIS-C and COVID-19 ARDS. Complement and coagulation activation were implicated in these clinical phenotypes, however there was contribution of FcGR and BCR activation in MIS-C and scavenging of heme and retinoid metabolism in COVID-19 ARDS. Conclusions: We show proteome differences in MIS-C and COVID-ARDS, although both show complement and coagulation dysregulation. The results may be helpful in developing therapeutic targets that could improve the outcomes for these children.
HostingRepository	PRIDE
AnnounceDate	2022-04-06
AnnouncementXML	Submission_2022-04-06_02:29:49.182.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jemma Wu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	TripleTOF 6600

Revision	Datetime	Status	ChangeLog Entry
0	2021-03-31 06:32:48	ID requested
⏵ 1	2022-04-06 02:29:49	announced

Dataset with its publication pending

ProteomeXchange project tag: Covid-19

submitter keyword: Proteomics, SWATH

Prof. Vera Ignjatovic
contact affiliation	Haematology Research Group, Murdoch Children's Research Institute
contact email	vera.ignjatovic@mcri.edu.au
lab head
Jemma Wu
contact affiliation	The Australia Proteome Analysis Facility
contact email	jemma.wu@mq.edu.au
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD025125
     1. Label: PRIDE project
     2. Name: Pathophysiological pathway differences in children who present with COVID-19 ARDS compared to COVID -19 induced MIS-C