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PXD025101

PXD025101 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleContribution of IFIX to nuclear and cytoplasmic proteome changes during immune signaling
DescriptionIFIX is a nuclear DNA sensor that is known to induce cytokine expression in response to both cytoplasmic DNA and foreign DNA in the nucleus. Here, we examine the concomitant nuclear and cytoplasmic proteome changes that are driven by IFIX during immune response to viral infection and transfection of viral DNA. Furthermore, we identify the posttranslational modifications present on the IFIX protein during HSV-1 infection.
HostingRepositoryPRIDE
AnnounceDate2021-06-02
AnnouncementXMLSubmission_2021-06-02_13:51:48.155.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterTim Howard
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606; scientific name: Human alphaherpesvirus 1; NCBI TaxID: 10298;
ModificationListphosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF; LTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-03-30 03:42:44ID requested
12021-06-02 13:51:48announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Innate immunity, nuclear DNA sensor, IFIX, PTM
Contact List
Ileana M Cristea
contact affiliationDepartment of Molecular Biology, Princeton University
contact emailicristea@princeton.edu
lab head
Tim Howard
contact affiliationPrinceton University
contact emailth12@princeton.edu
dataset submitter
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Dataset FTP location
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