PXD025066 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Furan warheads for covalent trapping of weak protein-protein interactions: specific cross-linking of thymosin β4 to actin |
Description | We describe furan as a triggerable ‘warhead’ for site-specific cross-linking using the actin and thymosin β4 (Tβ4)-complex as model of a weak and dynamic protein-protein interaction with known 3D structure and with application potential in disease contexts. The presented in vitro validation of covalently acting ‘furan-armed’ Tβ4-variants provides initial proof to further exploit furan-technology for covalent drug design. |
HostingRepository | PRIDE |
AnnounceDate | 2021-05-13 |
AnnouncementXML | Submission_2021-05-13_05:03:08.435.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD025066 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Marina Gay |
SpeciesList | scientific name: Oryctolagus sp. 'Rabbit_OD'; NCBI TaxID: 2665958; |
ModificationList | monohydroxylated residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-03-29 06:48:22 | ID requested | |
⏵ 1 | 2021-05-13 05:03:08 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Furan, protein-protein interactions, covalent, cross-link, cross-linked peptide, actin, Thymosin β4, mass spectrometry |
Contact List
Annemieke Madder |
contact affiliation | Organic and Biomimetic Chemistry Research Group, Department of Organic and Macromolecular Chemistry, Faculty of Science, Ghent University, Krijgslaan 281 S4, B-9000 Ghent, Belgium |
contact email | Annemieke.Madder@Ugent.be |
lab head | |
Marina Gay |
contact affiliation | Institute for Research in Biomedicine |
contact email | marina.gay@irbbarcelona.org |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/05/PXD025066 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD025066
- Label: PRIDE project
- Name: Furan warheads for covalent trapping of weak protein-protein interactions: specific cross-linking of thymosin β4 to actin